Redesigning Dad

Us New world Report                                                      10-31-01 November 5, 2001                                                      CP. 8 Redesigning Dad spermatozoan may be the best place to fix damage components. The technology is just slightly ready.

        What if a doctor could ingest corrected each defect in a mans sperm before fertizing the egg. This scenario is edging closer to reality now, as scientists visualise out how to slip new genes into the sperm-producing cells of lab animals, yielding genectically wangle sperm. Just last week they announced that the techonology worked as mean: Mice equipped with gene-adapted sperm puffed the gene to their descendants. Scientists argon thinking about using similar techniques to tinker with humans heritable inheritance to bring to genetic diseases and create genetically engineered superhummans.

        Ever since scientists started testing gene tharapy in clinical trials more than a decade ago, theyve concur never to alter genes in humman sperm, eggs, or embryos. But so far this strategy has been disappointing.

        Unlike sperm, human eggs are scarce and trick to work with, so scientists go for correcting genetic diseases in sperm. A man would first have a testicular biopsy to remove some of the primitive cells that develop into sperm.



Scientists would alter these cells by inserting genes or activating the cells DNA-repair mechanisms. Finaly, doctors would irradiate the mans testes to destroy any remaining sperm-producing cells and reimplant the altered ones. Then he would not pass on a genetic disease to his progeny.

        Other scientists are pushing more modest proposals in which they would produce altered sperm in the lab. before using the sperm to feast an egg, they could test it to make sure it was healthy and lacked the genetic defect. all one healthy sperm would be used to call back a child. Scientists working with animals have already developed...

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